LYNPARZA is a maintenance treatment option for patients with gBRCA-mutated metastatic pancreatic cancer that has not progressed on at least 16 weeks of first-line platinum-based chemotherapy.

Talk to Your Doctor About a Test to See if LYNPARZA® (olaparib) Is Right for You

Talk to your doctor about a test to see if LYNPARZA is right for you.

Not real patients

LYNPARZA® (olaparib) Tablets

LYNPARZA IS
a non-chemotherapy oral medication

LYNPARZA is the only treatment of its kind for patients with your specific type of cancer. It’s called a maintenance therapy because it can help maintain your status after chemotherapy.

Read more about LYNPARZA’s full dosing information

Not real patients

Patients on LYNPARZA had nearly twice as much time progression free than those on placebo (7.4 months vs 3.8 months).

LYNPARZA was studied in 154 patients with gBRCA-mutated metastatic pancreatic cancer whose disease did not progress on at least 16 weeks of first-line platinum-based chemotherapy. Ninety-two patients were given LYNPARZA and 62 patients were given placebo.

LYNPARZA® (olaparib) Patients Had Nearly Twice as Much Time Progression Free
LYNPARZA kept cancer from growing or returning for a median of 7.4 months compared with a median of 3.8 months in patients who were given placebo.
LYNPARZA® (olaparib) Reduced the Risk of Cancer Growing or Returning by 47% Compared to Placebo
LYNPARZA reduced the risk of cancer growing or returning by 47% compared with placebo.

Download: Looking ahead with LYNPARZA

Talk to Your Doctor About Getting BRCA Testing Talk to Your Doctor About Getting BRCA Testing

LYNPARZA is proven to help keep tumors from growing or returning in certain patients with gBRCA-mutated metastatic pancreatic cancer whose disease did not progress on at least 16 weeks of first-line platinum-based chemotherapy.

National guidelines recommend testing for a BRCA mutation for all patients with pancreatic cancer.

Patient Support

AstraZeneca Access 360 logo

AstraZeneca Access 360TM

Helps you access the care you need.

If your doctor has prescribed LYNPARZA, you may have questions. The AstraZeneca Access 360TM program can help. We can answer your questions about insurance coverage, out-of-pocket costs, and patient assistance programs. To learn more about the Access 360 program, please call 1-844-ASK-A360 (1-844-275-2360)1-844-ASK-A360 (1-844-275-2360) Monday - Friday, 8 AM - 8 PM ET or visit www.MyAccess360.com.

Commercially Insured Patients May Be Eligible to Receive LYNPARZA® (olaparib) With a $0 Co-pay

AstraZeneca strives to make LYNPARZA affordable by targeting a $0 co-pay for all eligible patients.

This is based on commercially insured patients. The average monthly cost for LYNPARZA may be greater than $0 for some patients.

Support Hotline for LYNPARZA® (olaparib)

Support Hotline

If you have any questions about LYNPARZA, speak with one of our specially trained nurses.
To speak with a nurse, call 1-800-770-8337call 1-800-770-8337.

How to take LYNPARZA

LYNPARZA can fit into your daily routine. You can take LYNPARZA with you wherever you go. It’s just two tablets (150 mg each), taken by mouth in the morning and in the evening, with or without food, totaling four tablets each day (600 mg daily dose).

2 Tablets of LYNPARZA® (olaparib) Taken in the Morning

2 TABLETS IN THE MORNING

(300 mg)

+
2 Tablets of LYNPARZA® (olaparib) Taken in the Evening

2 TABLETS IN THE EVENING

(300 mg)

Take doses 12 hours apart with or without food.

Images do not represent the actual tablet size of the tablets.

Important things to keep in mind when taking LYNPARZA

  • You should take LYNPARZA exactly as your doctor tells you
  • Swallow the tablets whole—do not chew, crush, dissolve, or divide them
  • Take each dose about 12 hours apart, with or without food
  • Do not take more than 4 tablets a day
  • Do not change your dose or stop taking LYNPARZA unless your doctor tells you to. Your doctor may temporarily stop treatment with LYNPARZA or change your dose of LYNPARZA if you experience side effects

Each treatment plan is unique and any questions you might have should be discussed with your doctor.

Foods to avoidAvoid grapefruit, grapefruit juice, Seville oranges and Seville orange juice during treatment with LYNPARZA since they may increase the level of LYNPARZA in your blood.

If you miss a doseTake your next dose at the usual scheduled time. Do not take an extra dose to make up for the one you missed.

If you take too muchCall your doctor or go to the nearest hospital emergency room right away.

Education and Finding Support May Make a Difference in Your Treatment Journey With LYNPARZA® (olaparib)

Education and support may help make a meaningful difference.

registration

Sign up forMy LYNPARZA Support Program

MyLYNPARZA is a support program that is unique to your treatment journey. We developed this program with one goal in mind: to be there for you and your loved ones.

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WHAT IS LYNPARZA?

LYNPARZA is a prescription medicine used to treat adults who have:

  • metastatic pancreatic cancer with a certain type of abnormal inherited BRCA gene. LYNPARZA is used as a maintenance treatment after your cancer has not progressed on at least 16 weeks of treatment with platinum-based chemotherapy. Your healthcare provider will perform a test to make sure LYNPARZA is right for you

It is not known if LYNPARZA is safe and effective in children.

IMPORTANT SAFETY INFORMATION

LYNPARZA may cause serious side effects, including:

Bone marrow problems called Myelodysplastic Syndrome (MDS) or Acute Myeloid Leukemia (AML). Some people who have ovarian cancer or breast cancer and who have received previous treatment with chemotherapy, radiotherapy, or certain other medicines for their cancer have developed MDS or AML during treatment with LYNPARZA. MDS or AML may lead to death. If you develop MDS or AML, your healthcare provider will stop treatment with LYNPARZA.

Symptoms of low blood cell counts are common during treatment with LYNPARZA, but can be a sign of serious bone marrow problems, including MDS or AML. Symptoms may include weakness, weight loss, fever, frequent infections, blood in urine or stool, shortness of breath, feeling very tired, bruising or bleeding more easily.

Your healthcare provider will do blood tests to check your blood cell counts:

  • before treatment with LYNPARZA
  • every month during treatment with LYNPARZA
  • weekly if you have low blood cell counts that last a long time. Your healthcare provider may stop treatment with LYNPARZA until your blood cell counts improve

Lung problems (pneumonitis). Tell your healthcare provider if you have any new or worsening symptoms of lung problems, including shortness of breath, fever, cough, or wheezing. Your healthcare provider may do a chest x-ray if you have any of these symptoms. Your healthcare provider may temporarily or completely stop treatment if you develop pneumonitis. Pneumonitis may lead to death.

Blood clots (venous thromboembolic events). Some people may develop a blood clot in a deep vein, usually in the leg (venous thrombosis) or a clot in the lungs (pulmonary embolism), which may be severe or lead to death. Tell your healthcare provider right away if you have any symptoms such as pain or swelling in an extremity, shortness of breath, chest pain, breathing that is more rapid than normal (tachypnea), or heart beats faster than normal (tachycardia). Your healthcare provider will monitor you for these symptoms and may prescribe blood thinner medicine.

Before taking LYNPARZA, tell your healthcare provider about all of your medical conditions, including if you:

  • have lung or breathing problems
  • have kidney problems
  • are pregnant, become pregnant, or plan to become pregnant. LYNPARZA can harm your unborn baby and may cause loss of pregnancy (miscarriage)
    • If you are able to become pregnant, your healthcare provider may do a pregnancy test before you start treatment with LYNPARZA
    • Females who are able to become pregnant should use effective birth control (contraception) during treatment with LYNPARZA and for 6 months after the last dose of LYNPARZA. Talk to your healthcare provider about birth control methods that may be right for you. Tell your healthcare provider right away if you become pregnant or think you might be pregnant following treatment with LYNPARZA
    • Males with female partners who are pregnant or able to become pregnant should use effective birth control (contraception) during treatment with LYNPARZA and for 3 months after the last dose of LYNPARZA
    • Do not donate sperm during treatment with LYNPARZA and for 3 months after your last dose
  • are breastfeeding or plan to breastfeed. It is not known if LYNPARZA passes into your breast milk. Do not breastfeed during treatment with LYNPARZA and for 1 month after receiving the last dose of LYNPARZA. Talk to your healthcare provider about the best way to feed your baby during this time

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Taking LYNPARZA and certain other medicines may affect how LYNPARZA works and may cause side effects.

How should I take LYNPARZA?

  • Take LYNPARZA tablets exactly as your healthcare provider tells you
  • Do not change your dose or stop taking LYNPARZA unless your healthcare provider tells you to. Your healthcare provider may temporarily stop treatment with LYNPARZA or change your dose of LYNPARZA if you experience side effects
  • Your healthcare provider will decide how long you stay on treatment
  • Do not take more than 4 LYNPARZA tablets in 1 day. If you have any questions about LYNPARZA, talk to your healthcare provider or pharmacist
  • Take LYNPARZA by mouth 2 times a day
  • Each dose should be taken about 12 hours apart
  • Swallow LYNPARZA tablets whole. Do not chew, crush, dissolve, or divide the tablets
  • Take LYNPARZA with or without food
  • If you miss a dose of LYNPARZA, take your next dose at your usual scheduled time. Do not take an extra dose to make up for a missed dose
  • If you take too much LYNPARZA, call your healthcare provider or go to the nearest hospital emergency room right away

What should I avoid while taking LYNPARZA?

Avoid grapefruit, grapefruit juice, Seville oranges, and Seville orange juice during treatment with LYNPARZA since they may increase the level of LYNPARZA in your blood.

LYNPARZA may cause serious side effects (see above). The most common side effects of LYNPARZA are:

  • nausea or vomiting. Tell your healthcare provider if you get nausea or vomiting. Your healthcare provider may prescribe medicines to treat these symptoms
  • tiredness or weakness
  • low red blood cell counts
  • diarrhea
  • loss of appetite
  • headache
  • changes in the way food tastes
  • cough
  • low white blood cell counts
  • shortness of breath
  • dizziness
  • indigestion or heartburn
  • low platelet counts

These are not all the possible side effects of LYNPARZA. Call your healthcare provider for medical advice about side effects.

You may report side effects related to AstraZeneca products by clicking here. If you prefer to report these to the FDA, either visit www.FDA.gov/medwatch or call 1-800-FDA-1088.

Please see complete Prescribing Information, including Medication Guide.

IMPORTANT SAFETY INFORMATION

Read More

LYNPARZA may cause serious side effects, including:

Bone marrow problems called Myelodysplastic Syndrome (MDS) or Acute Myeloid Leukemia (AML). Some people who have ovarian cancer or breast cancer and who have received previous treatment with chemotherapy, radiotherapy, or certain other medicines for their cancer have developed MDS or AML during treatment with LYNPARZA. MDS or AML may lead to death. If you develop MDS or AML, your healthcare provider will stop treatment with LYNPARZA.